Grapefruit juice increases sildenafil blood levels, potentially enhancing side effects including severe headaches, flushing, visual disturbances, and dangerous drops in blood pressure.
How it works
CYP3A4 inhibition by grapefruit reduces first-pass metabolism of sildenafil, increasing drug exposure.
What to do: Avoid grapefruit juice on the day you take sildenafil. If you take it regularly for pulmonary hypertension, avoid grapefruit entirely.
Source: FDA Viagra Prescribing Information
🍔 Heavy Fatty Meals⚡ Moderate
A large, high-fat meal significantly delays how quickly sildenafil works. The time to maximum effect may increase by up to 1 hour.
What to do: Take sildenafil on an empty stomach or after a light meal for fastest effect.
Source: FDA Viagra Prescribing Information
Disclaimer: Educational purposes only. Based on FDA drug labeling and NIH MedlinePlus. Consult your pharmacist or physician before changing your diet while on medication.
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