hATTR Amyloidosis
Drug Prices & Savings

Hereditary transthyretin-mediated amyloidosis is a rare, progressive disease caused by misfolded TTR proteins depositing in nerves and the heart. RNA therapies and TTR stabilizers slow progression.

hATTR Amyloidosis Medications & Prices

Compare retail costs, GoodRx prices, and manufacturer patient assistance programs (PAP) for hattr amyloidosis drugs.

Prices are approximate retail estimates. Actual costs vary by pharmacy, location, and insurance. Always verify with your pharmacist.

Frequently Asked Questions

Common questions about hATTR Amyloidosis medications, costs, and savings programs.

What is hATTR amyloidosis?
Hereditary transthyretin-mediated (hATTR) amyloidosis is a rare, progressive fatal disease caused by TTR gene mutations. Misfolded TTR protein accumulates in peripheral nerves and the heart, causing polyneuropathy and/or cardiomyopathy.
What is the difference between Amvuttra and Onpattro?
Both are siRNA therapies from Alnylam that silence TTR gene expression. Amvuttra is given quarterly by subQ injection; Onpattro every 3 weeks by IV. Amvuttra has largely replaced Onpattro due to convenience.
Does Pfizer have a patient assistance program for Vyndamax?
Yes. Pfizer's RxPathways program provides Vyndamax at no cost or reduced cost to eligible uninsured/underinsured patients. Visit pfizerrxpathways.com or call 1-844-989-PATH.
How much does Amvuttra cost?
Amvuttra's list price is approximately $35,000/month. Alnylam's Alnylam Assist program provides copay assistance for commercially insured patients and free drug for uninsured qualifying patients.
Are there clinical trials for hATTR amyloidosis?
Yes. Multiple Phase 2/3 trials are ongoing. Visit clinicaltrials.gov and search "transthyretin amyloidosis." The Amyloidosis Research Consortium (arci.org) maintains a trial finder.

Newly Diagnosed with hATTR Amyloidosis?

A quick-start guide to understanding your diagnosis and managing medication costs.

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Understand Your Treatment

Ask your doctor about first-line vs. specialty medications, expected timeline, and monitoring requirements. Write down all questions before appointments.

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Check for Patient Assistance

Before filling any prescription, ask your pharmacist about manufacturer copay cards, PAP programs, and GoodRx pricing. Many specialty drugs are free or near-free for qualifying patients.

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See a Specialist

For complex conditions, a specialist (rheumatologist, neurologist, pulmonologist, etc.) provides access to newer therapies and clinical trials unavailable at the primary care level.

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Connect with Others

Patient advocacy organizations offer peer support, educational resources, and can connect you with financial assistance navigators who specialize in your condition.

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Public Voices on hATTR Amyloidosis

Many public figures live with hattr amyloidosis and speak openly about their experience.

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