Alcohol worsens depression, anxiety, and insomnia — the very conditions sertraline treats. Combined, they can cause dangerous sedation, impaired judgment, and suicidal thoughts.
How it works
Both alcohol and sertraline affect serotonin pathways. Alcohol is a CNS depressant that counteracts antidepressant benefits.
What to do: Avoid alcohol entirely during depression and anxiety treatment. Even small amounts can trigger setbacks.
Source: FDA Zoloft Prescribing Information; American Psychiatric Association Guidelines
🌿 St. John's Wort⚠️ High Risk
Combining sertraline with St. John's Wort can cause serotonin syndrome — a potentially life-threatening condition with agitation, high fever, rapid heartbeat, tremors, and sweating.
How it works
Both sertraline and St. John's Wort increase serotonin activity. Combined, serotonin accumulates to toxic levels.
What to do: Never take St. John's Wort with any prescribed antidepressant (SSRIs, SNRIs, MAOIs). Tell every healthcare provider what supplements you take.
Source: FDA Sertraline Prescribing Information; FDA Safety Advisory on Serotonin Syndrome
Disclaimer: Educational purposes only. Based on FDA drug labeling and NIH MedlinePlus. Consult your pharmacist or physician before changing your diet while on medication.
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