Methotrexate is already processed by the liver. Alcohol is also liver-toxic. Combined, they dramatically increase the risk of serious liver damage, fibrosis, and cirrhosis, even at low doses.
How it works
Both methotrexate and alcohol independently cause hepatotoxicity. Their combination produces synergistic liver damage.
What to do: Avoid alcohol completely while taking methotrexate. Liver function tests (LFTs) should be monitored regularly.
Source: FDA Methotrexate Prescribing Information (Black Box Warning); ACR Rheumatoid Arthritis Guidelines
Disclaimer: Educational purposes only. Based on FDA drug labeling and NIH MedlinePlus. Consult your pharmacist or physician before changing your diet while on medication.
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