This is the most extensively studied grapefruit-drug interaction. Grapefruit increases felodipine blood levels by 2-3x, causing excessive blood pressure drop, severe headaches, flushing, and heart palpitations.
What to do: Completely avoid grapefruit and grapefruit juice. The effect lasts 24+ hours after drinking grapefruit juice.
Source: FDA Plendil Prescribing Information; Bailey DG et al., The Lancet (original grapefruit discovery study)
Disclaimer: Educational purposes only. Based on FDA drug labeling and NIH MedlinePlus. Consult your pharmacist or physician before changing your diet while on medication.
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