St. John's Wort reduces digoxin blood levels by up to 25%, potentially making this critical heart medication ineffective for controlling heart rate and heart failure symptoms.
How it works
St. John's Wort induces P-glycoprotein and CYP3A4, increasing digoxin elimination and reducing blood concentrations.
What to do: Do NOT use St. John's Wort while taking digoxin. Report it immediately to your cardiologist if you have been taking it.
Source: FDA Drug Safety Communication on St. John's Wort
Disclaimer: Educational purposes only. Based on FDA drug labeling and NIH MedlinePlus. Consult your pharmacist or physician before changing your diet while on medication.
📡 You're offline — showing cached content. Connect to search new recipes or check interactions.
💊
Add FreeRx to Home Screen
Get faster access to your health profile, recipes & med checker.
💊 Save up to 80% on prescriptions — Free Rx discount card, no signup required.