Grapefruit dramatically increases cyclosporine blood levels — potentially by 2-3 fold. This significantly raises the risk of cyclosporine toxicity, including kidney damage and high blood pressure.
How it works
Grapefruit inhibits both intestinal and hepatic CYP3A4 and P-glycoprotein, the primary mechanisms responsible for cyclosporine metabolism.
What to do: Completely avoid grapefruit and grapefruit juice while taking cyclosporine. Blood cyclosporine levels should be monitored regularly.
Source: FDA Sandimmune/Neoral Prescribing Information; KDIGO Transplant Guidelines
Disclaimer: Educational purposes only. Based on FDA drug labeling and NIH MedlinePlus. Consult your pharmacist or physician before changing your diet while on medication.
📡 You're offline — showing cached content. Connect to search new recipes or check interactions.
💊
Add FreeRx to Home Screen
Get faster access to your health profile, recipes & med checker.
💊 Save up to 80% on prescriptions — Free Rx discount card, no signup required.