Combining Xanax with alcohol is life-threatening. Both drugs depress the central nervous system — together they can cause respiratory failure, coma, and death.
How it works
Both benzodiazepines and alcohol enhance GABA inhibitory signaling. Combined CNS depression can overwhelm respiratory centers.
What to do: Never drink alcohol while taking alprazolam or any benzodiazepine. If you drink regularly, tell your doctor before starting benzodiazepine therapy.
Source: FDA Xanax Prescribing Information (Black Box Warning)
🍊 Grapefruit / Grapefruit Juice⚡ Moderate
Grapefruit can increase alprazolam blood levels, prolonging and intensifying sedation, dizziness, and coordination problems.
How it works
Grapefruit inhibits CYP3A4, the primary enzyme responsible for alprazolam metabolism.
What to do: Avoid grapefruit and grapefruit juice while taking Xanax. The effect can last 24 hours or more.
Source: FDA Xanax Prescribing Information
Disclaimer: Educational purposes only. Based on FDA drug labeling and NIH MedlinePlus. Consult your pharmacist or physician before changing your diet while on medication.
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